Role for the Bacterial Signal Indole in Promoting Epithelial Cell Barrier Function
نویسندگان
چکیده
منابع مشابه
Role for the Bacterial Signal Indole in Promoting Epithelial Cell Barrier Function
Interkingdom (IK) signaling, in which pathogenic bacteria recognize human hormones in the gastrointestinal tract to initiate infection, has recently emerged as an important contributor to gastrointestinal tract infections. While a majority of studies have primarily focused on the effect of host molecules on pathogens, recent work from our lab has demonstrated that human intestinal epithelial ce...
متن کاملThe bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation.
Interkingdom signaling is established in the gastrointestinal tract in that human hormones trigger responses in bacteria; here, we show that the corollary is true, that a specific bacterial signal, indole, is recognized as a beneficial signal in intestinal epithelial cells. Our prior work has shown that indole, secreted by commensal Escherichia coli and detected in human feces, reduces pathogen...
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The intestinal epithelium is a critical component of the gut barrier. Composed of a single layer of intestinal epithelial cells (IECs) held together by tight junctions, this delicate structure prevents the transfer of harmful microorganisms, antigens, and toxins from the gut lumen into the circulation. The equilibrium between the rate of apoptosis and shedding of senescent epithelial cells at t...
متن کاملCommensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon
Microbiota have been shown to have a great influence on functions of intestinal epithelial cells (ECs). The role of indole as a quorum-sensing (QS) molecule mediating intercellular signals in bacteria has been well appreciated. However, it remains unknown whether indole has beneficial effects on maintaining intestinal barriers in vivo. In this study, we analyzed the effect of indole on ECs usin...
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BACKGROUND The PTEN phosphatase acts on phosphatidylinositol 3,4,5-triphosphates resulting from phosphatidylinositol 3-kinase (PI3K) activation. PTEN expression has been shown to be decreased in colorectal cancer. Little is known however as to the specific cellular role of PTEN in human intestinal epithelial cells. The aim of this study was to investigate the role of PTEN in human colorectal ca...
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ژورنال
عنوان ژورنال: Journal of Epithelial Biology and Pharmacology
سال: 2012
ISSN: 1875-0443
DOI: 10.2174/1875044301205010032